Nail: software for high-speed, high-sensitivity protein sequence annotation.

ABSTRACT: " Fast is fine, but accuracy is final. " -- Wyatt Earp.

Background

The extreme diversity of newly sequenced organisms and considerable scale of modern sequence databases lead to a tension between competing needs for sensitivity and speed in sequence annotation, with multiple tools displacing the venerable BLAST software suite on one axis or another. Alignment based on profile hidden Markov models (pHMMs) has demonstrated state of art sensitivity, while recent algorithmic advances have resulted in hyper-fast annotation tools with sensitivity close to that of BLAST.

Results

Here, we introduce a new tool that bridges the gap between advances in these two directions, reaching speeds comparable to fast annotation methods such as MMseqs2 while retaining most of the sensitivity offe

SUBMITTER: Roddy JW 

PROVIDER: S-EPMC10862755 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature