Metapopulation model of phage therapy of an acute Pseudomonas aeruginosa lung infection.

ABSTRACT: Infections caused by multi-drug resistant (MDR) pathogenic bacteria are a global health threat. Phage therapy, which uses phage to kill bacterial pathogens, is increasingly used to treat patients infected by MDR bacteria. However, the therapeutic outcome of phage therapy may be limited by the emergence of phage resistance during treatment and/or by physical constraints that impede phage-bacteria interactions in vivo. In this work, we evaluate the role of lung spatial structure on the efficacy of phage therapy for Pseudomonas aeruginosa infection. To do so, we developed a spatially structured metapopulation network model based on the geometry of the bronchial tree, and included the emergence of phage-resistant bacterial mutants and host innate immune responses. We model the ec

SUBMITTER: Rodriguez-Gonzalez RA 

PROVIDER: S-EPMC10862780 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature