Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis Perturbations.

ABSTRACT: Imbalances in mitochondrial proteostasis are associated with pathologic mitochondrial dysfunction implicated in etiologically-diverse diseases. This has led to considerable interest in defining the biological mechanisms responsible for regulating mitochondria in response to mitochondrial stress. Numerous stress responsive signaling pathways have been suggested to regulate mitochondria in response to proteotoxic stress, including the integrated stress response (ISR), the heat shock response (HSR), and the oxidative stress response (OSR). Here, we define the specific stress signaling pathways activated in response to mitochondrial proteostasis stress by monitoring the expression of sets of genes regulated downstream of each of these signaling pathways in published Perturb-seq datasets from K

SUBMITTER: Madrazo N 

PROVIDER: S-EPMC10862789 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature