Global Release of Translational Repression Across <i>Plasmodium's</i> Host-to-Vector Transmission Event.

ABSTRACT: Malaria parasites must be able to respond quickly to changes in their environment, including during their transmission between mammalian hosts and mosquito vectors. Therefore, before transmission, female gametocytes proactively produce and translationally repress mRNAs that encode essential proteins that the zygote requires to establish a new infection. This essential regulatory control requires the orthologues of DDX6 (DOZI), LSM14a (CITH), and ALBA proteins to form a translationally repressive complex in female gametocytes that associates with many of the affected mRNAs. However, while the release of translational repression of individual mRNAs has been documented, the details of the global release of translational repression have not. Moreover, the changes in spatial arrangement and com

SUBMITTER: Rios KT 

PROVIDER: S-EPMC10862809 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature