AI prediction of cardiovascular events using opportunistic epicardial adipose tissue assessments from CT calcium score.

ABSTRACT:

Background

Recent studies have used basic epicardial adipose tissue (EAT) assessments (e.g., volume and mean HU) to predict risk of atherosclerosis-related, major adverse cardiovascular events (MACE).

Objectives

Create novel, hand-crafted EAT features, "fat-omics", to capture the pathophysiology of EAT and improve MACE prediction.

Methods

We segmented EAT using a previously-validated deep learning method with optional manual correction. We extracted 148 radiomic features (morphological, spatial, and intensity) and used Cox elastic-net for feature reduction and prediction of MACE.

Results

Traditional fat features gave marginal prediction (EAT-volume/EAT-mean-HU/BMI gave C-index 0.53/0.55/0.57, respectively). Significant improvement was obtained with 15 fat-omics

SUBMITTER: Hu T 

PROVIDER: S-EPMC10862931 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature