Protein identification for stroke progression via Mendelian Randomization in Million Veteran Program and UK Biobank.

ABSTRACT:

Background

Individuals who have experienced a stroke, or transient ischemic attack, face a heightened risk of future cardiovascular events. Identification of genetic and molecular risk factors for subsequent cardiovascular outcomes may identify effective therapeutic targets to improve prognosis after an incident stroke.

Methods

We performed genome-wide association studies (GWAS) for subsequent major adverse cardiovascular events (MACE) (N_cases=51,929, N_cntrl=39,980) and subsequent arterial ischemic stroke (AIS) N_cases=45,120, N_cntrl=46,789) after first incident stroke within the Million Veteran Program and UK Biobank. We then used genetic variants associated with proteins (pQTLs) to determine the effect of 1,463 plasma protein abun

SUBMITTER: Elmore A 

PROVIDER: S-EPMC10863017 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature