RNA sequencing reveals differential long noncoding RNA expression profiles in bacterial and viral meningitis in children.

ABSTRACT:

Background

We aimed to investigate the involvement of long non-coding RNA (lncRNA) in bacterial and viral meningitis in children.

Methods

The peripheral blood of five bacterial meningitis patients, five viral meningitis samples, and five healthy individuals were collected for RNA sequencing. Then, the differentially expressed lncRNA and mRNA were detected in bacterial meningitis vs. controls, viral meningitis vs. healthy samples, and bacterial vs. viral meningitis patients. Besides, co-expression and the competing endogenous RNA (ceRNA) networks were constructed. Receiver operating characteristic curve (ROC) analysis was performed.

Results

Compared with the control group, 2 lncRNAs and 32 mRNAs were identified in bacterial meningitis patients, and 115 lncRNAs and 54 m

SUBMITTER: Li X 

PROVIDER: S-EPMC10863080 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature