Effects of circadian clock disruption on gene expression and biological processes in Aedes aegypti.

ABSTRACT:

Background

This study explores the impact of disrupting the circadian clock through a Cycle gene knockout (KO) on the transcriptome of Aedes aegypti mosquitoes. The investigation aims to uncover the resulting alterations in gene expression patterns and physiological processes.

Results

Transcriptome analysis was conducted on Cyc knockout (AeCyc^-/-) and wild-type mosquitoes at four time points in a light-dark cycle. The study identified system-driven genes that exhibit rhythmic expression independently of the core clock machinery. Cyc disruption led to altered expression of essential clock genes, affecting metabolic processes, signaling pathways, stimulus responses and immune responses. Notably, gene ontology enrichment of odorant binding proteins, indicating the cl

SUBMITTER: Shetty V 

PROVIDER: S-EPMC10863115 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature