Molecular characterization of extensively drug-resistant hypervirulent Pseudomonas aeruginosa isolates in China.

ABSTRACT:

Background

Recently, extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) isolates have been increasingly detected and posed great challenges to clinical anti-infection treatments. However, little is known about extensively resistant hypervirulent P. aeruginosa (XDR-hvPA). In this study, we investigate its epidemiological characteristics and provide important basis for preventing its dissemination.

Methods

Clinical XDR-PA isolates were collected from January 2018 to January 2023 and identified using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry; antibiotic susceptibility testing was performed by broth microdilution method, and minimum inhibitory concentrations (MICs) were evaluated. Virulence was evaluated using the Galleria mellonella in

SUBMITTER: Li J 

PROVIDER: S-EPMC10863134 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature