Metagenomic next-generation sequencing of plasma cell-free DNA improves the early diagnosis of suspected infections.

ABSTRACT:

Background

Metagenomic next-generation sequencing (mNGS) could improve the diagnosed efficiency of pathogens in bloodstream infections or sepsis. Little is known about the clinical impact of mNGS test when used for the early diagnosis of suspected infections. Herein, our main objective was to assess the clinical efficacy of utilizing blood samples to perform mNGS for early diagnosis of suspected infections, as well as to evaluate its potential in guiding antimicrobial therapy decisions.

Methods

In this study, 212 adult hospitalized patients who underwent blood mNGS test in the early stage of suspected infections were enrolled. Diagnostic efficacy of mNGS test and blood culture was compared, and the clinical impact of mNGS on clinical care was analyzed.

Results

In our

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10863141 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature