From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models.

ABSTRACT:

Background

Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Although the overall survival of patients with NB has improved in the last years, more than 50% of high-risk patients still undergo a relapse. Thus, in the era of precision/personalized medicine, the need for high-risk NB patient-specific therapies is urgent.

Methods

Within the PeRsonalizEd Medicine (PREME) program, patient-derived NB tumors and bone marrow (BM)-infiltrating NB cells, derived from either iliac crests or tumor bone lesions, underwent to histological and to flow cytometry immunophenotyping, respectively. BM samples containing a NB cells infiltration from 1 to 50 percent, underwent to a subsequent NB cells enrichment using immune-magnetic manip

SUBMITTER: Capasso M 

PROVIDER: S-EPMC10863144 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature