Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas.

ABSTRACT:

Background

Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrP^C) stands out as a potential candidate for new therapies. Encoded by the PRNP gene, PrP^C can present increased expression levels in GBM, impacting cell proliferation, growth, migration, invasion and stemness. Nevertheless, the exact molecular mechanisms through which PRNP/PrP^C modulates key aspects of GBM biology remain elusive.

Methods

To elucidate the implications of PRNP/PrP^C in the biology of this cancer, we analyzed publicly available RNA sequencing (RNA-seq) data of patient-derived GBMs from four independent studi

SUBMITTER: Boccacino JM 

PROVIDER: S-EPMC10863147 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature