Comparison of the adherence of nontypeable haemophilus influenzae to lung epithelial cells.

ABSTRACT:

Objective

Nontypeable Haemophilus influenzae (NTHi) plays an important role in respiratory tract infections, and adherence to lung epithelial cells is the first step in lung infections. To explore the role of NTHi in childhood lung infections, a comparative study was conducted on the adherence of strains isolated from sputum culture and bronchoalveolar lavage fluid to A549 lung epithelial cells.

Methods

Haemophilus influenzae strains were obtained from the sample bank of Shenzhen Children's Hospital, and identified as NTHi via PCR detection of the capsule gene bexA. NTHi obtained from healthy children's nasopharyngeal swabs culture were selected as the control group, and a comparative study was conducted on the adherence of strains isolated from sputum culture or bronchoalve

SUBMITTER: Rong Y 

PROVIDER: S-EPMC10863205 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature