Review of brachytherapy clinical trials: a cross-sectional analysis of ClinicalTrials.gov.

ABSTRACT:

Introduction

Characterizing the landscape of clinical trials including brachytherapy can provide an overview of the current status and research trends which may guide further areas of investigation.

Method

We queried 449,849 clinical trials from the ClinicalTrials.gov registry using brachytherapy-related keywords from 1980 to 2023, yielding 245 multi-arm and 201 single-arm, brachytherapy trials. Multi-arm and single-arm brachytherapy trials were compared using 12 trial protocol elements.

Results

The number of trials including brachytherapy has increased over time, with over 60% of trials registered in 2010 onwards. The majority of clinical trials were Phase 2 or 3, evaluated both safety and efficacy, and were funded by academic sponsors. The most common tumor sites ev

SUBMITTER: Chen D 

PROVIDER: S-EPMC10863227 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature