Metabolic dormancy in Chlamydia trachomatis treated with different antibiotics.

ABSTRACT: Diseases caused by Chlamydia spp. are often associated with persistent infections. Chlamydial persistence is commonly associated with a unique non-infectious intracellular developmental form, termed an aberrant form. Although infectious chlamydiae can be cultured consistently in cells stressed to aberrancy, their role in persistence is not clear. Recovery from antibiotic stress was explored as a model to determine how survival of non-aberrant chlamydiae, in the presence of fully inhibitory drug concentrations, may participate in persistence. Assays included incubation in quinolones, tetracyclines, or chloramphenicol for differing lengths of time, followed by an extended recovery period in antibiotic-free media. Culturable elementary bodies were not detected during treatment with eac

SUBMITTER: Rockey DD 

PROVIDER: S-EPMC10863404 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature