Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling.

ABSTRACT: Macrophages act as a first line of defense against pathogens. Against Aspergillus fumigatus, a fungus with pathogenic potential in immunocompromised patients, macrophages can phagocytose fungal spores and inhibit spore germination to prevent the development of tissue-invasive hyphae. However, the cellular pathways that macrophages use to accomplish these tasks and any roles macrophages have later in infection against invasive forms of fungi are still not fully known. Rac-family Rho GTPases are signaling hubs for multiple cellular functions in leukocytes, including cell migration, phagocytosis, reactive oxygen species (ROS) generation, and transcriptional activation. We therefore aimed to further characterize the function of macrophages against A. fumigatus in an in vivo

SUBMITTER: Tanner CD 

PROVIDER: S-EPMC10863406 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature