Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC10863409 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Yu Ying Y Tang Xinming X Duan Chunhui C Suo Jingxia J Crouch Colin C Zhang Sixin S Liu Xianyong X Liu Jie J Bruton Beth B Tarpey Ian I Suo Xun X
Infection and immunity 20240105 2
Using transgenic <i>Eimeria</i> spp. to deliver exogenous antigens is a viable option for developing multivalent live vaccines. Previous research revealed that the location of antigen expression in recombinant <i>Eimeria</i> dictates the magnitude and type of immune responses. In this study, we constructed genetically modified <i>Eimeria acervulina</i> that expressed VP2 protein, a protective antigen from infectious bursal disease virus (IBDV), on the surface or in the microneme of sporozoites. ...[more]