Proinflammatory CD14^highCD16^low monocytes/macrophages prevail in Treponema phagedenis-associated bovine digital dermatitis.

ABSTRACT: Digital dermatitis (DD) is a skin disease in cattle characterized by painful inflammatory ulcerative lesions in the feet, mostly associated with local colonization by Treponema spp., including Treponema phagedenis. The reason why most DD lesions remain actively inflamed and progress to chronic conditions despite antibiotic treatment remains unknown. Herein, we show an abundant infiltration of proinflammatory (CD14^highCD16^low) monocytes/macrophages in active DD lesions, a skin response that was not mitigated by topical treatment with oxytetracycline. The associated bacterium, T. phagedenis, isolated from DD lesions in cattle, when injected subcutaneously into mice, induced abscesses with a local recruitment of Ly6G⁺ neutrophils and proin

SUBMITTER: Lahiri P 

PROVIDER: S-EPMC10863414 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature