Staphylococcus aureus senses human neutrophils via PerR to coordinate the expression of the toxin LukAB.

ABSTRACT: Staphylococcus aureus is a gram-positive pathogen that poses a major health concern, in part due to its large array of virulence factors that allow infection and evasion of the immune system. One of these virulence factors is the bicomponent pore-forming leukocidin LukAB. The regulation of lukAB expression is not completely understood, especially in the presence of immune cells such as human polymorphonuclear neutrophils (hPMNs). Here, we screened for transcriptional regulators of lukAB during the infection of primary hPMNs. We uncovered that PerR, a peroxide sensor, is vital for hPMN-mediated induction of lukAB and that PerR upregulates cytotoxicity during the infection of hPMNs. Exposure of S. aureus to hydrogen peroxide (H₂O₂) alo

SUBMITTER: Savin A 

PROVIDER: S-EPMC10863418 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature