Characterization of the immunosuppressive environment induced by larval Echinococcus granulosus during chronic experimental infection.

ABSTRACT: The larval stage of Echinococcus granulosus causes the chronic infection known as cystic echinococcosis, deploying strong inhibitory mechanisms on host immune responses. Using experimental intraperitoneal infection in C57BL/6 mice, we carried out an in-depth analysis of the local changes in macrophage populations associated with chronic infection. In addition, we analyzed T cells and relevant soluble mediators. Infected animals showed an increase in local cell numbers, mostly accounted for by eosinophils, T cells, and macrophages. Within macrophage populations, the largest increases in cell numbers corresponded to resident large peritoneal macrophages (LPM). Monocyte recruitment appeared to be active, as judged by the increased number of monocytes and cells in the process of differe

SUBMITTER: Grezzi L 

PROVIDER: S-EPMC10863420 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature