Tumor treating fields increases blood-brain barrier permeability and relative cerebral blood volume in patients with glioblastoma.

ABSTRACT:

Background and objective

200 kHz tumor treating fields (TTFields) is clinically approved for newly-diagnosed glioblastoma (nGBM). Because its effects on conventional surveillance MRI brain scans are equivocal, we investigated its effects on perfusion MRI (pMRI) brain scans.

Methods

Each patient underwent institutional standard pMRI: dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) pMRI at three time points: baseline, 2-, and 6-months on-adjuvant therapy. At each timepoint, the difference between T1 pre- versus post-contrast tumor volume (ΔT1) and these pMRI metrics were evaluated: normalized and standardized relative cerebral blood volume (nRCBV, sRCBV); fractional plasma volume (V_p), volume of extravascular extracellular space (EES) per v

SUBMITTER: Iv M 

PROVIDER: S-EPMC10863570 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature