APOL1 Risk Variants Associate With the Prevalence of Stroke in African American Current and Past Smokers.

ABSTRACT:

Background

African American smokers have 2.5 times higher risk for stroke compared with nonsmokers (higher than other races). About 50% of the African American population carry 1 or 2 genetic variants (G1 and G2; rare in other races) of the apolipoprotein L1 gene (APOL1). Studies showed these variants may be associated with stroke. However, the role of the APOL1 risk variants in tobacco-related stroke is unknown.

Methods and results

In a cross-sectional study, we examined whether APOL1 risk variants modified the relationship between tobacco smoking and stroke prevalence in 513 African American adults recruited at University of California, San Francisco. Using DNA, plasma, and questionnaires we determined APOL1 variants, smoking status, and stroke

SUBMITTER: Rakic JM 

PROVIDER: S-EPMC10863786 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature