Topiramate dosage optimization for effective antiseizure management via population pharmacokinetic modeling.

ABSTRACT:

Objective

Despite the suggested topiramate serum level of 5-20 mg/L, numerous institutions have observed substantial drug response at lower levels. We aim to investigate the correlation between topiramate serum levels, drug responsiveness, and adverse events to establish a more accurate and tailored therapeutic range.

Methods

We retrospectively analyzed clinical data collected between January 2017 and January 2022 at Seoul National University Hospital. Drug responses to topiramate were categorized as "insufficient" or "sufficient" by reduction in seizure frequency ≥ 50%. A population pharmacokinetic model estimated serum levels from spot measurements. ROC curve analysis determined the optimal cutoff values.

Results

A total of 389 epilepsy patients were reviewed having

SUBMITTER: Lee S 

PROVIDER: S-EPMC10863906 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature