Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients.

ABSTRACT:

Objective

Although acute brain infarcts are common after surgical aortic valve replacement (SAVR), they are often unassociated with clinical stroke symptoms. The relationship between clinically "silent" infarcts and in-hospital delirium remains uncertain; obscured, in part, by how infarcts have been traditionally summarized as global metrics, independent of location or structural consequence. We sought to determine if infarct location and related structural connectivity changes were associated with postoperative delirium after SAVR.

Methods

A secondary analysis of a randomized multicenter SAVR trial of embolic protection devices (NCT02389894) was conducted, excluding participants with clinical stroke or incomplete neuroimaging (N = 298; 39% female, 7% non-White, 74 ± 7 years

SUBMITTER: Browndyke JN 

PROVIDER: S-EPMC10863920 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature