Association of genetic and sulcal traits with executive function in congenital heart disease.

ABSTRACT:

Objective

Persons with congenital heart disease (CHD) are at increased risk of neurodevelopmental disabilities, including impairments to executive function. Sulcal pattern features correlate with executive function in adolescents with single-ventricle heart disease and tetralogy of Fallot. However, the interaction of sulcal pattern features with genetic and participant factors in predicting executive dysfunction is unknown.

Methods

We studied sulcal pattern features, participant factors, and genetic risk for executive function impairment in a cohort with multiple CHD types using stepwise linear regression and machine learning.

Results

Genetic factors, including predicted damaging de novo or rare inherited variants in neurodevelopmental disabilities risk genes, apolipo

SUBMITTER: Maleyeff L 

PROVIDER: S-EPMC10863927 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature