Slc12a2 loss in insulin-secreting β-cells links development of overweight and metabolic dysregulation to impaired satiation control of feeding.

ABSTRACT: Male mice lacking the Na⁺-K⁺-2Cl^- cotransporter Slc12a2 (Nkcc1) specifically in insulin-secreting β-cells (Slc12a2^βKO) have reduced β-cell mass and mild β-cell secretory dysfunction associated with overweight, glucose intolerance, insulin resistance, and metabolic abnormalities. Here, we confirmed and extended previous results to female Slc12a2^βKO mice, which developed a similar metabolic syndrome-like phenotype as males, albeit milder. Notably, male and female Slc12a2^βKO mice developed overweight without consuming excess calories. Analysis of the feeding microstructure revealed that young lean Slc12a2^βKO male mice ate meals of higher caloric content and at a relatively lo

SUBMITTER: Rathod YD 

PROVIDER: S-EPMC10864024 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature