Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.

ABSTRACT: The cell cycle is a highly regulated process in which proteins involved in cell cycle progression exhibit periodic expression patterns, controlled by specific mechanisms such as transcription, translation, and degradation. However, the precise mechanisms underlying the oscillations of mRNA levels in cell cycle regulators are not fully understood. In this study, we observed that the stability of cyclin D1 (CCND1) mRNA fluctuates during the cell cycle, with increased stability during interphase and decreased stability during the M phase. Additionally, we identified a key RNA binding protein, positive coactivator 4 (PC4), which plays a crucial role in stabilizing CCND1 mRNA and regulating its periodic expression. Moreover, the binding affinity of PC4 to CCND1 mRNA is modulated by two cell cyc

SUBMITTER: Pan Q 

PROVIDER: S-EPMC10864110 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature