Value of CT-based radiomics in evaluating the response of bone metastases to systemic drug therapy in breast cancer patients.

ABSTRACT:

Background

This study aimed to investigate the value of nonenhanced computed tomography (CT)-based radiomics in determining disease progression in breast cancer patients with bone marrow metastases and to develop a model for assessing treatment efficacy.

Methods

A total of 134 breast cancer patients with bone metastases were enrolled from three hospitals. Nonenhanced CT was performed after two cycles of drug treatment. The images were categorized into an invalid and a valid group according to disease progression status. The largest osteolytic lesions' maximum cross-sections in the CT images were selected as regions of interest (ROIs) for feature extraction. Variance threshold, SelectKBest, and least absolute shrinkage and selection operator (LASSO) were used to reduce featur

SUBMITTER: He M 

PROVIDER: S-EPMC10864122 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature