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ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC10864181 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Zhao Siming S Crouse Wesley W Qian Sheng S Luo Kaixuan K Stephens Matthew M He Xin X
Nature genetics 20240126 2
Many methods have been developed to leverage expression quantitative trait loci (eQTL) data to nominate candidate genes from genome-wide association studies. These methods, including colocalization, transcriptome-wide association studies (TWAS) and Mendelian randomization-based methods; however, all suffer from a key problem-when assessing the role of a gene in a trait using its eQTLs, nearby variants and genetic components of other genes' expression may be correlated with these eQTLs and have d ...[more]