Association between lipid profile in early pregnancy and the risk of congenital heart disease in offspring: a prospective cohort study.

ABSTRACT: This study aimed to investigate the association of lipid profile in early pregnancy and the risk of congenital heart disease (CHD) in offspring. This study was a prospective cohort design based on the Fujian Birth Cohort Study in China. We recruited pregnant women at ≤ 14 weeks of gestation between 2019 and 2022, and all participants in this study filled out the questionnaire about periconceptional exposure. Simultaneously, we collected participants' fasting blood samples to measure their lipid profile by automatic biochemical analyzer. The outcome was defined as offspring with CHD. A multivariable logistic regression model was used to calculate adjusted odds ratio (AOR) risk estimates, which indicate the associations between maternal lipid profiles and CHD in offspring. Restricted cubic s

SUBMITTER: Zhao M 

PROVIDER: S-EPMC10864369 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature