Evolution of guanylate binding protein genes shows a remarkable variability within bats (Chiroptera).

ABSTRACT:

Background

GBPs (guanylate binding proteins), an evolutionary ancient protein family, play a key role in the host's innate immune response against bacterial, parasitic and viral infections. In Humans, seven GBP genes have been described (GBP1-7). Despite the interest these proteins have received over the last years, evolutionary studies have only been performed in primates, Tupaia and rodents. These have shown a pattern of gene gain and loss in each family, indicative of the birth-and-death evolution process.

Results

In this study, we analysed the evolution of this gene cluster in several bat species, belonging to the Yangochiroptera and Yinpterochiroptera sub-orders. Detailed analysis shows a conserved synteny and a gene expansion and loss histor

SUBMITTER: Pinheiro A 

PROVIDER: S-EPMC10864436 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature