Context association in pyramidal neurons through local synaptic plasticity in apical dendrites.

ABSTRACT: The unique characteristics of neocortical pyramidal neurons are thought to be crucial for many aspects of information processing and learning in the brain. Experimental data suggests that their segregation into two distinct compartments, the basal dendrites close to the soma and the apical dendrites branching out from the thick apical dendritic tuft, plays an essential role in cortical organization. A recent hypothesis states that layer 5 pyramidal cells associate top-down contextual information arriving at their apical tuft with features of the sensory input that predominantly arrives at their basal dendrites. It has however remained unclear whether such context association could be established by synaptic plasticity processes. In this work, we formalize the objective of such context asso

SUBMITTER: Baronig M 

PROVIDER: S-EPMC10864492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature