Unexpected reaction of "wild-type" gastrointestinal stromal tumor to imatinib: case report and literature review.

ABSTRACT:

Background

Most of gastrointestinal stromal tumors (GISTs) are driven by mutations in the KIT/PDGFRA genes and can benefit from TKIs treatment. However, a small subset of GIST (10%-15%) are called "wild-type" GISTs due to the lack of these mutations. Theoretically, they would not benefit from TKIs treatment and may even develop resistance. Therefore, this unexpected response may challenge inherent perceptions. Herein, we present a case of giant wild-type GIST exhibiting an unexpected response to imatinib(IM), followed by laparoscopic surgical resection. Subsequently, potential underlying mechanisms are discussed.

Case description

This case describes a 57-year-old man who presented with abdominal pain for two weeks. CT revealed a massive lesion near the splenic hilum along th

SUBMITTER: He Y 

PROVIDER: S-EPMC10864548 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature