Bioinformatics analysis proposes a possible role for long noncoding RNA MIR17HG in retinoblastoma.

ABSTRACT:

Background

Retinoblastoma (RB) is the most common prevalent intraocular malignancy among infants and children, particularly in underdeveloped countries. With advancements in genomics and transcriptomics, noncoding RNAs have been increasingly utilized to investigate the molecular pathology of diverse diseases.

Aims

This study aims to establish the competing endogenous RNAs network associated with RB, analyse the function of mRNAs and lncRNAs, and finds the relevant regulatory network.

Methods and results

This study establishes a network of competing endogenous RNAs by Spearman correlation analysis and prediction based on RB patients and healthy children. Enrichment analyzes based on Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes are conducted to analyze

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10864729 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature