Prenatal and postnatal influences on behavioral development in a mouse model of preconceptional stress.

ABSTRACT: Depression during pregnancy is detrimental for the wellbeing of the expectant mother and can exert long-term consequences on the offspring's development and mental health. In this context, both the gestational environment and the postpartum milieu may be negatively affected by the depressive pathology. It is, however, challenging to assess whether the contributions of prenatal and postnatal depression exposure are distinct, interactive, or cumulative, as it is unclear whether antenatal effects are due to direct effects on fetal development or because antenatal symptoms continue postnatally. Preclinical models have sought to answer this question by implementing stressors that induce a depressive-like state in the dams during pregnancy and studying the effects on the offspring. The aim of ou

SUBMITTER: Scarborough J 

PROVIDER: S-EPMC10865047 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature