Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates.

ABSTRACT:

Importance

The US heart allocation system prioritizes medically urgent candidates with a high risk of dying without transplant. The current therapy-based 6-status system is susceptible to manipulation and has limited rank ordering ability.

Objective

To develop and validate a candidate risk score that incorporates current clinical, laboratory, and hemodynamic data.

Design, setting, and participants

A registry-based observational study of adult heart transplant candidates (aged ≥18 years) from the US heart allocation system listed between January 1, 2019, and December 31, 2022, split by center into training (70%) and test (30%) datasets. Adult candidates were listed between January 1, 2019, and December 31, 2022.

Main outcomes and measures

A US candidate risk sco

SUBMITTER: Zhang KC 

PROVIDER: S-EPMC10865158 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature