Deletion in a regulatory region is associated with underexpression of miR-148b‑3p in patients with prostate cancer.

ABSTRACT: Prostate cancer (PCa) is the leading cause of cancer-related death in men. This pathology is complex and heterogeneous; therefore, elucidating the molecular mechanisms that lead to its origin and progression is imperative. MicroRNAs (miRNAs or miRs) are part of the epigenetic machinery that regulates the expression of human genes, therefore, mutations in the genes that encode them can lead to a dysregulation in their expression, which directly impacts their target genes, which could be oncogenes or tumor suppressor genes. In PCa several dysregulated expression levels of miRNAs are associated with perturbed cellular processes. A differential expression of miRNAs such as miR-145-5p and miR-148-3p has been observed in PCa, possibly due to mutations in regions near the miRNAs. However, the mol

SUBMITTER: Bergez-Hernandez F 

PROVIDER: S-EPMC10865175 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature