Curative effects of tectochrysin on paraquat-instigated testicular toxicity in rats: A biochemical and histopathological based study.

ABSTRACT:

Background

Paraquat (PQ) is a herbicide that is used globally in the agriculture sector to eradicate unwanted weeds, however it also induces significant damages in various organs of the body such as testes. Tectochrysin (TEC) is an important flavonoid that shows versatile therapeutic potentials. Currently, there is no established antidote to cure PQ-induced testicular toxicity.

Objective

The present study was conducted to evaluate the ameliorative effects of TEC against PQ prompted testicular damage.

Methods

Sprague-Dawley rats (n = 48) were used to conduct the trial. Rats were allocated in to 4 groups i.e., Control, PQ administrated group (5 mgkg^-1), PQ + TEC co-administrated group (5 mgkg^-1 + 2.5 mgkg^-1) and TEC only administrated gr

SUBMITTER: Ijaz MU 

PROVIDER: S-EPMC10865255 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature