FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing.

ABSTRACT: As current chemo- and photodynamic cancer therapies are associated with severe side effects due to a lack of specificity and to systemic toxicity, innovative solutions in terms of targeting and controlled functionality are in high demand. Here, we present the development of a polymersome nanocarrier equipped with targeting molecules and loaded with photosensitizers for efficient uptake and light-activated cell killing. Polymersomes were self-assembled in the presence of photosensitizers from a mixture of nonfunctionalized and functionalized PDMS-b-PMOXA diblock copolymers, the latter designed for coupling with targeting ligands. By encapsulation inside the polymersomes, the photosensitizer Rose Bengal was protected, and its uptake into cells was mediated by the nanocarrier. Inhibito

SUBMITTER: Skowicki M 

PROVIDER: S-EPMC10865352 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature