Protein-Rich Rafts in Hybrid Polymer/Lipid Giant Unilamellar Vesicles.

ABSTRACT: Considerable attention has been dedicated to lipid rafts due to their importance in numerous cell functions such as membrane trafficking, polarization, and signaling. Next to studies in living cells, artificial micrometer-sized vesicles with a minimal set of components are established as a major tool to understand the phase separation dynamics and their intimate interplay with membrane proteins. In parallel, mixtures of phospholipids and certain amphiphilic polymers simultaneously offer an interface for proteins and mimic this segregation behavior, presenting a tangible synthetic alternative for fundamental studies and bottom-up design of cellular mimics. However, the simultaneous insertion of complex and sensitive membrane proteins is experimentally challenging and thus far has been large

SUBMITTER: Otrin N 

PROVIDER: S-EPMC10865357 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature