Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease.

ABSTRACT:

Introduction

While Alzheimer's disease (AD) is defined by amyloid-β plaques and tau tangles in the brain, it is evident that many other pathophysiological processes such as inflammation, neurovascular dysfunction, oxidative stress, and metabolic derangements also contribute to the disease process and that varying contributions of these pathways may reflect the heterogeneity of AD. Here, we used a previously validated panel of cerebrospinal fluid (CSF) biomarkers to explore the degree to which different pathophysiological domains are dysregulated in AD and how they relate to each other.

Methods

Twenty-five CSF biomarkers were analyzed in individuals with a clinical diagnosis of AD verified by positive CSF AD biomarkers (AD, n = 54) and cognitively unimpaired controls n

SUBMITTER: Trombetta BA 

PROVIDER: S-EPMC10865489 | biostudies-literature | 2024 Jan-Mar

REPOSITORIES: biostudies-literature