Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality, especially in teenagers to young adults. In recent decades, different biomarkers and/or staining protocols have been employed to evaluate the post-injury development of pathological structures, but they have produced many contradictory findings. Since correctly identifying the underlying neuroanatomical changes is critical to advancing TBI research, we compared three commonly used markers for their ability to detect TBI pathological structures: Fluoro-Jade C, the rabbit monoclonal antibody Y188 against amyloid precursor protein and the NeuroSilver kit were used to stain adjacent slices from naïve or injured mouse brains harvested at different time points from 30 min to 3 months after lateral fluid percussion injury

SUBMITTER: Xiong G 

PROVIDER: S-EPMC10865493 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature