Cai's prescription inhibits granulosa cell apoptosis through ARHGAP4 on poor ovarian responders.

ABSTRACT:

Purpose

Poor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai's Prescription of Tonifying Kidney and Strengthening Vitals (Cai's Prescription) has yielded satisfactory results for POR treatment clinically, but systematic scientific research of Cai's Prescription is not well reported. This study aimed to investigate the clinical effect of Cai's Prescription on poor ovarian responders and its biological mechanism.

Methods

Serum was collected from poor ovarian responders, and IL-1β, INFγ, FSH, E₂ and AMH levels were analyzed by ELISA. Ovarian antral follicles were identified and counted using transvaginal ultrasound. The embryo quality grading were done on day 3 after retrieval. We used high-throughput sequen

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10865665 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature