Implementation of type 1 diabetes genetic risk screening in children in diverse communities: the Virginia PrIMeD project.

ABSTRACT:

Background

Population screening for risk of type 1 diabetes (T1D) has been proposed to identify those with islet autoimmunity (presence of islet autoantibodies). As islet autoantibodies can be transient, screening with a genetic risk score has been proposed as an entry into autoantibody testing.

Methods

Children were recruited from eight general pediatric and specialty clinics across Virginia with diverse community settings. Recruiters in each clinic obtained informed consent/assent, a medical history, and a saliva sample for DNA extraction in children with and without a history of T1D. A custom genotyping panel was used to define T1D genetic risk based upon associated SNPs in European- and African-genetic ancestry. Subjects at "high genetic risk" were offered a separate blo

SUBMITTER: Guertin KA 

PROVIDER: S-EPMC10865687 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature