Alterations of gut microbiota in infants with biliary atresia identified by 16S rRNA-sequencing.

ABSTRACT:

Background

Biliary atresia (BA) is a severe neonatal disease with progressive intra- and extra-hepatic bile ducts inflammation and hepatic fibrosis. Characterization of gut microbiome profiles in infants with biliary atresia can provide valuable information and potential disease biomarkers. Our study aims to explore the relationship between gut microbiota and biliary atresia.

Methods

16 S ribosomal RNA (rRNA) gene sequencing was carried out to identify the differences in composition and diversity of gut microbiota between infants with BA and healthy subjects. A total of 31 infants with biliary atresia and 20 healthy subjects were recruited.

Results

The composition of gut microbiota in BA group was significantly different with the normal control group (P < 0.05) and th

SUBMITTER: Liu F 

PROVIDER: S-EPMC10865691 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature