A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation.

ABSTRACT:

Background

Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications may arise, namely cuff displacement or nerve compression, due to a poor adaptability to variable nerve shapes and sizes encountered in vivo. Improvements in cuff design, materials, closing mechanism and surgical approach are necessary to overcome these issues.

Methods

In this work, we propose a microfabricated multi-channel silicone-based soft cuff electrode with a novel easy-to-implant and size-adaptable design and evaluate a number of essential features such as nerve-cuff contact, nerve compression, cuff locking stability,

SUBMITTER: Paggi V 

PROVIDER: S-EPMC10865708 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature