Evaluation of SNPs associated with mammographic density in European women with mammographic density in Asian women from South-East Asia.

ABSTRACT:

Purpose

Mammographic density (MD), after accounting for age and body mass index (BMI), is a strong heritable risk factor for breast cancer. Genome-wide association studies (GWAS) have identified 64 SNPs in 55 independent loci associated with MD in women of European ancestry. Their associations with MD in Asian women, however, are largely unknown.

Method

Using linear regression adjusting for age, BMI, and ancestry-informative principal components, we evaluated the associations of previously reported MD-associated SNPs with MD in a multi-ethnic cohort of Asian ancestry. Area and volumetric mammographic densities were determined using STRATUS (N = 2450) and Volpara™ (N = 2257). We also assessed the associations of these SNPs with breast cancer risk in an Asian population of 14,

SUBMITTER: Mariapun S 

PROVIDER: S-EPMC10865780 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature