Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb) can adopt a non-growing dormant state during infection that may be critical to both active and latent tuberculosis. During dormancy, Mtb is widely tolerant toward antibiotics, a significant obstacle in current anti-tubercular drug regimens, and retains the ability to persist in its environment. We aimed to identify novel mechanisms that permit Mtb to survive dormancy in an in vitro carbon starvation model using transposon insertion sequencing and gene expression analysis. We identified a previously uncharacterized component of the lipid transport machinery, omamC, which was upregulated and required for survival during carbon starvation. We show that OmamC plays a role both in increasing fatty acid stores during growth in rich media and

SUBMITTER: Sturm A 

PROVIDER: S-EPMC10865790 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature