Yersiniabactin is a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli.

ABSTRACT: Siderophores are secreted ferric ion chelators used to obtain iron in nutrient-limited environmental niches, including human hosts. While all Escherichia coli express the enterobactin (Ent) siderophore system, isolates from patients with urinary tract infections additionally express the genetically distinct yersiniabactin (Ybt) siderophore system. To determine whether the Ent and Ybt systems are functionally redundant for iron uptake, we compared the growth of different isogenic siderophore biosynthetic mutants in the presence of transferrin, a human iron-binding protein. We observed that Ybt expression does not compensate for deficient Ent expression following low-density inoculation. Using transcriptional and product analysis, we found this non-redundancy to be attributable to a d

SUBMITTER: Heffernan JR 

PROVIDER: S-EPMC10865836 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature