A CO₂ sensing module modulates β-1,3-glucan exposure in <i>Candida albicans</i>.

ABSTRACT: Microbial species capable of co-existing with healthy individuals, such as the commensal fungus Candida albicans, exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathogen-associated molecular patterns (PAMPs) at their cell surface. We reported previously that C. albicans actively reduces the exposure of the proinflammatory PAMP, β-1,3-glucan, at its cell surface in response to host-related signals such as lactate and hypoxia. Here, we show that clinical isolates of C. albicans display phenotypic variability with respect to their lactate- and hypoxia-induced β-1,3-glucan masking. We have exploited this variability to identify responsive and non-responsive clinical isolates. We then performed RNA se

SUBMITTER: Avelar GM 

PROVIDER: S-EPMC10865862 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature